October 2012

4 Grants/$112,820 Awarded

Randomized Clinical Trial of the Safety and Efficacy of Brain Oxygen Monitoring in the Management of Severe Traumatic Brain Injury (BOOST-II)

Amount: $25,000
Primary Investigator: Norberto Andaluz, MD
Category: Traumatic Injury

To enroll patients in an ongoing National Institutes of Health (NIH) study testing the effect of clinical interventions on the outcome of severe traumatic brain injury, focusing on the use of brain oxygen monitoring. This is a large, multi-centered, randomized trial to determine whether attempts to provide more oxygen to the brain after the initial trauma could aid in recovery and reduce permanent damage.

Effects of Dexmedetomodine on Inflammatory Markers in Serum and Cerebrospinal Fluid in Patients with Aneurysmal Subarachnoid Hemorrhage: A Randomized, Prospective Pilot Study

Amount: $22,820
Primary Investigator: Mark Magner, MD
Category: Cerebrovascular

To test the effectiveness of an alternative drug sedation regimine in patients who have suffered a ruptured aneurysm. Researchers wish to determine the proposed therapy's efficacy in reducing extended inflammation in the brain and the resulting additional neurologic problems that can occur as a result.

In Vivo MR Microscopy of Novel Proteolipid Nanovesicle Incorporating Gadolium Chelate

Amount: $50,000
Primary Investigator: Xiaoyang Qi, PhD
Category: Brain Tumor

To develop a specific MRI dye for glioblastoma multiforme, an aggressive brain tumor that is notoriously difficult to treat. Detection of this tumor is challenging and current MRI techniques cannot identify all of the tumor present. The goal of this project is to develop a novel chemical that could be used in conjunction with MRI to better detect tumor cells, which would enable more effective and accurate targeting for surgery and radiation.

Developing Tools for Biomedical Informatics Research

Amount: $15,000
Primary Investigator: J. Adam Wilson, PhD
Category: Research Investment

To build upon and enhance the capablities of a novel bedside monitoring system developed for an ongoing project funded by the U.S. Department of Defense.  Additional modifications to the system will enhance data integration, and will benefit research collaborations at the University of Cincinnati, Cincinnati Children's Hospital Medical  Center, and with other laboratories worldwide.

April 2012

2 Grants/$78,556 Awarded

Spatio-temporal Relationship of Glutamate-induced Excitotoxicity to Peri-infarct Depolarizations in Focal Cerebral Ischemia

Amount: $28,556
Primary Investigator: Vince DiNapoli, MD, PhD
Category: Cerebrovascular

To monitor the progression of electro-chemical cellular reactions that take place before, during, and after a stroke to provide insight into how damaged areas of the brain affect the surrounding tissue, with the intent of developing therapies to prevent additional damage from occurring.

Targeting the EGFR Signaling Network in Human Malignant Brain Tumors

Amount: $50,000
Primary Investigator: James Driscoll, MD, PhD
Category: Brain Tumor

To test thousands of pharmacological compounds for signs of effectiveness in the treatment of glioblastoma multiforme. This particular type of tumor presents special problems because it is infiltrative and cannot be removed in one piece; individual tumor cells tend to survive surgery, radiation, and chemotherapy. Researchers are looking for small molecules that kill cancers on a cell-by-cell basis.