Mayfield Research Services has dedicated staff to conduct clinical trials, submit research protocols and proposals, aid in data collection, assist with statistical analysis, and support final journal publication with medical writing, illustration, and presentation support through GliaMedia. Mayfield benefits from a network of collaborative partners like the Lindner Research Center at The Christ Hospital, OHC at the Jewish Hospital, and the TriHealth Hatton Research Institute.

Clinical Trials

CARIS tumor molecular profiling for right-in-time clinical trials | Dr. Warnick

Patients with brain tumors will undergo a genomic molecular profile evaluation for precision medicine. This study hopes to improve the lives of patients suffering from brain cancer by matching a patient's specific tumor biomarkers with targeted therapy trials. If matched, patients are rapidly enrolled and begin treatment within weeks under the care of their local doctors — eliminating stress of traveling to access clinical trials in other cities.

GammaTile v SRS

GammaTile v SRS newly diagnosed metastasis | Drs. DiNapoli and Gozal

This study has the goal of understanding outcomes in patients receiving Gamma Tiles vs Stereotactic Radiation Therapy for the treatment of newly diagnosed brain metastasis (cancer that has spread to the brain from another part of body).

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GammaTile, STaRT observational study in neoplasms | Drs. DiNapoli and Gozal

A longitudinal observational study designed to understand long term outcomes in patients who receive Gamma Tile therapy.


Decreasing incidence of adjacent segment disease with physical therapy of the multifidus muscles after surgery | Dr. Bohinski, Physical Therapy

This study hopes to understand how increasing the strength of the innermost layer of muscle, called the multifidus, in the back can prevent future spine surgery due to adjacent level disease. Ultrasound will be used to measure the muscle cross section throughout an 8-week physical therapy program.


M6-C artificial disc versus anterior cervical discectomy and fusion | Dr. Krueger

This study compares a novel artificial cervical disc device, called Spinal Kinetics M6-C, to anterior cervical discectomy and fusion (ACDF). This study aims to understand if the M6-C artificial disc is better, worse, or the same as ACDF for pain relief and long-term outcomes. The unique design of M6-C has a compressible viscoelastic nuclear core and an annular structure. Artificial disc surgery preserves motion of the neck, whereas fusion stops motion.


TLIF with InFuse bone graft for degenerative spine | Dr. Bohinski

Evaluating the use of Infuse™ Bone Graft material in Transforaminal Lumbar Interbody Fusion (TLIF). A TLIF is a type of surgery that fuses – or joins – bones of the spine through a posterior approach. It is used to treat painful degenerative conditions of the lumbar spine. This study will determine if Infuse bone biologics are better, worse, or the same as the current standard of care (bone allograft).

Restless leg

Spinal cord stimulation for restless legs syndrome | Dr. Orlando

This study hopes to understand whether spinal cord stimulation can improve the lives of patients suffering from restless legs syndrome through the use of spinal cord stimulation.


Palarum sensor socks measure gait and balance to quantify functional improvement with spinal cord stimulation | Drs. Orlando and Iding

Palarum sensor socks measure gait and balance to quantify functional improvement with spinal cord stimulation (SCS). This study aims to understand the correlation between gait and spinal cord stimulation success in patients suffering from chronic back pain.


CREST-2: Carotid Revascularization and medical management for carotid stenosis| Dr. Ringer

CREST-2: Carotid Revascularization and Medical Management for Carotid Stenosis. This study compares three methods of stroke prevention: 1) intensive medical management alone compared to 2) intensive medical management in combination with a procedure to remove the plaque in your carotid artery, either surgical carotid endarterectomy, or 3) endovascular carotid angioplasty and stenting.


Post-market study long-term safety of LVIS device | Dr. Ringer

The study is a multi-center data collection of aneurysm patients treated with the LVIS device with up to 5 years follow-up. The MicroVention LVIS EVO is a braided self-expanding stent that is placed inside the parent artery to bridge across wide-neck aneurysms. The stent holds aneurysm coils in place during embolization.

CT Chiari

Chiari Surgical Success Scale trial | Dr. Gozal

The Chiari Surgical Success Scale is a prospective multicenter patient registry that will combine patient data from all over the world to understand better how to treat and improve outcomes for patients suffering from Chiari malformation. A Chiari is a condition where the lower part of the brain, called the cerebellar tonsil, herniates down through the skull and into the spinal canal. This blocks the normal flow of cerebrospinal fluid (CSF) and causes pressure build-up.


William Tobler, MD | Spinal Elements

Evaluation of safety and efficacy of the Luna XD spinal fusion device. This retrospective study evaluated patient data to understand the safety and efficacy of the LUNA expandable interbody device for minimally invasive spinal procedures.

Collaborative Studies

Mayfield also participates in meaningful large-scale clinical research on a national level by working with research consortiums including the International Radiosurgery Research Foundation (IRRF), the Endovascular Neurosurgery Research Group (ENRG), and the Bobby Jones CSF Chiari Clinical Research Consortium.

Select Publications

  • Warnick RE, Paddick I, Mathieu D, et al. The relevance of biologically effective dose for pain relief and sensory dysfunction after Gamma Knife radiosurgery for trigeminal neuralgia: an 871-patient multicenter study. J Neurosurg. 2024 Feb 16:1-13. doi: 10.3171/2023.12.JNS231569.
  • Parney IF, Warnick RE, Lang FF, et al. The AANS/CNS Section on Tumors: a summary of 40 years of advocacy to advance the care of patients with brain and spine tumors. J Neurosurg. 2024 Jan 26:1-7. doi: 10.3171/2023.12.JNS232781.
  • Warnick RE. Treatment of adverse radiation effects with Boswellia serrata after failure of pentoxifylline and vitamin E: illustrative cases. J Neurosurg Case Lessons. 2023 Jan 30;5(5):CASE22488. doi: 10.3171/CASE22488.
  • Ringer AJ, et al. ENRG Collection: Endovascular Video Series. Op Neurosurg 2021


Quality Outcomes Database (QOD)

Since 2018, Mayfield has participated in the NeuroPoint Alliance's key suite of registries, the Quality Outcomes Database (QOD). The registry establishes benchmarks and generates data about the quality of neurological care.

Research Grants

The Mayfield Foundation also provides funding for innovative research that holds great promise. These seed grants from Mayfield have shown to be successful in helping researchers develop the data and proposals for larger granting agencies. Grantees have secured over $9,000,000 in federal funding from 2013-2018. With such outcomes, the Mayfield Foundation termed these grants, "Spark Grants" in that they spark a large bonfire of success.

Past grant recipients

ALS research

Novel ALS Treatments Targeting Muscle Ciliary Neurotrophic Factor Signaling

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Nimjee Lab

Potentially Safer, More Effective Clot-Buster on Horizon with Help from Mayfield Foundation

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Lober Lab

Wright State University researcher making progress on the study of pediatric brain cancer with Mayfield Foundation grant

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Final moments: understanding the neurobiology of dying

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